I liked your post, and to paraphrase the American philosopher Donald Rumsfeld there are probably unknown unknowns.
We might discover something (perhaps many things) that makes interstellar travel easier than it would otherwise appear to be.
I don't
think anyone here is claiming that science or technology will plateau, though- just that advances might not be limitless.
But, increased knowledge
might find a factor or factors that make interstellar flight even more difficult than many might think it to be at present. The universe is under no obligation to make things easy for us.
One finding which might have implications for long duration crewed spaceflight in the near future might be
spaceflight-associated neuro-ocular syndrome (SANS).
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Astronauts have recently been discovered to have impaired vision, with a presentation that resembles syndromes of elevated intracranial pressure on Earth.
J.S. Lawley, L.G. Petersen et al. (2017), "Effect of gravity and microgravity on intracranial pressure",
The Journal of Physiology 595 (6)
https://physoc.onlinelibrary.wiley.com/doi/pdfdirect/10.1113/JP273557
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Most of the astronauts onboard the International Space Station (ISS) develop visual impairment and ocular structural changes that are not fully reversible upon return to earth.
N. Alperin, A.M. Bagci (2018), "Spaceflight-Induced Visual Impairment and Globe Deformations in Astronauts Are Linked to Orbital Cerebrospinal Fluid Volume Increase",
Acta neurochirurgica supp. 216
(link here)
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Spaceflight associated neuro-ocular syndrome (SANS) is common amongst astronauts on long duration space missions and is associated with signs consistent with elevated cerebrospinal fluid (CSF) pressure. Additionally, CSF pressure has been found to be elevated in a significant proportion of astronauts in whom lumbar puncture was performed after successful mission completion.
W.H. Morgan, J. Khoo et al. (2023), "Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change",
npj Microgravity 9
https://www.nature.com/articles/s41526-023-00269-0
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In the past, many terms were used to describe the symptoms of malaise, nausea, vomiting, and vertigo, though longer duration spaceflights have increased the prevalence of overlapping symptoms of headache and visual disturbance. Spaceflight-induced visual pathology is thought to be a manifestation of increased intracranial pressure (ICP) because of its similar presentation to cases of known intracranial hypertension on Earth as well as the documentation of increased ICP by lumbar puncture in symptomatic astronauts upon return to gravity.
A.P. Michael, K. Marshall-Bowman (2015), "Spaceflight-Induced Intracranial Hypertension",
Aerospace medicine and human performance 86 (6),
https://pubmed.ncbi.nlm.nih.gov/26099128/
There is some evidence that effects on vision may persist post-mission, at least in some astronauts.
Spaceflight-associated choroidal folds (wrinkling of the tissues behind the retina) does appear to persist, albeit without detected effects on vision so far.
Anecdotally, there is concern at NASA that intracranial pressure may also remain elevated post-mission, and/or might become more prevalent on missions of longer duration:
At least one of the authors of "Mean intracranial pressure monitoring by a non-invasive audiological technique: a pilot study"
(A. Reid, R.J. Marchbanks et al. 1989,
Journal of Neurology, Neurosurgery and Psychiatry 52 (5),
https://jnnp.bmj.com/content/52/5/610) continued researching non-invasive ICP monitoring and has worked with NASA in more recent years (2010s+) in an attempt to develop reliable non-invasive ICP monitoring for use in-flight because of this concern.
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"SANS represents a critical risk for deep space exploration, where astronauts will experience spaceflight for longer periods of time and cannot easily return to Earth to address a medical emergency," says HRP chief scientist Jennifer Fogarty.
"The idea of embarking on a long-duration flight to Mars without having made this discovery is mind-boggling," Barratt adds. "We would have had people taking voyages of up to three years and coming back with all these problems that would have taken us forever to figure out."
NASA website article
International Space Station Research Keeps an Eye on Vision Changes in Space, Melissa Gaskill, 04 August 2020
https://www.nasa.gov/humans-in-spac...arch-keeps-an-eye-on-vision-changes-in-space/
Should be said, while effects of SANS on the eye are indisputable, there isn't a clear consensus that raised ICP is the cause.
In "Long-duration spaceflight alters estimated intracranial pressure and cerebral blood velocity", 2021,
The Journal of Physiology 599 (4), 2021
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP280318,
Ken-Ichi Iwasaki, Yojiro Ogawa et al. found post-flight ICP
lower in 9 out of 11 subjects (only 2 S's demonstrated optic disc oedema; both had temporarily raised ICPs.) This appears to contradict related studies.
The authors acknowledge their technique for estimating ICP was not definitive. Michael and Marshall-Bowman (ibid.) and Morgan, Khoo et al. (ibid.) refer to documented raised cerebrospinal fluid pressures found on lumbar puncture of returned astronauts, a better indicator of ICP.
Alperin and Bagci (ibid.) argue that increased orbital (anatomic, not astronomical) CSF pressure might cause the eye deformations seen in astronauts without a general increase in ICP.
Y. Martin Paez, L.I Mudie and P.S. Subramanian (2020) point out
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Two main hypotheses are proposed for the pathophysiology of SANS. The first being elevated intracranial pressure and the second compartmentalization of CSF to the globe. These hypotheses are not mutually exclusive...
"Spaceflight Associated Neuro-Ocular Syndrome (SANS): A Systematic Review and Future Directions",
Eye and Brain (2020)12
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585261/
Martin Paez, Mudie and Subramanian later refer to the more recent paper
"Visual changes after space flight: is it really caused by increased intracranial tension? A systematic review",
R. Elwy, M.A. Soliman, A.A. Hasanain et al. (2020),
Journal of Neurosurgical Sciences 64 (5),
https://pubmed.ncbi.nlm.nih.gov/32347675/, whose authors are more certain:
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Conclusions: Exposure to microgravity increases ICP possibly precipitating ocular changes. Whether other factors come into play is the subject of investigation. Further randomized studies and methods of direct ICP measurement during spaceflight are needed.
I read somewhere- and can't find again- that the ISS has a small number of adjustable pairs of glasses for astronauts whose vision deteriorates.
If long duration missions can cause raised ICP, that might be harder to mitigate, particularly if ICP continues to rise over time.
One factor which
might help a little is reducing the carbon dioxide content of the atmosphere of crewed spacecraft, high blood carbon dioxide can increase ICP.
On the ISS, atmospheric CO
View attachment 68963 might be 5000 ppm, higher at some times. NASA believes this cause some lethargy and headaches amongst crew (not surprised!)
"
In-Flight Carbon Dioxide Exposures and Related Symptoms: Association, Susceptibility, and Operational Implications", a NASA technical publication (NASA/TP–2010– 216126), J. Law, S. Watkins, D. Alexander (2010), found via Internet Archive/ Wayback Machine,
PDF attached.