well, you quoted "There were no cases of myocarditis (heart inflammation), anaphylaxis or deaths among ages 5-11 in the clinical trials.", so that looks like no data, but it's not: broadly speaking, with 1500 particpamts and no events, we can be fairly sure from that data that the risks are smaller than 0.2% , and possibly a lot less than that. That's what I was referring to when I said the data shows the vaccine is "essentially safe".data on the specific points i quoted from your article. not data on whether the vaccine is effective.
It’s a concern for many who are still hesitant to get the COVID-19 vaccine: How could we possibly know whether long-term side effects are possible, when COVID-19 vaccines just began clinical trials in 2020?
Look at vaccine history
One thing we can do is look at all vaccines we’ve produced and studied over time.
Going back at least as far as the polio vaccine, which was widely released to the public in the 1960s, we’ve never seen a vaccination with long-term side effects, meaning side effects that occur several months or years after injection.
Unlike many medications, which are taken daily, vaccines are generally one-and-done. Medicines you take every day can cause side effects that reveal themselves over time, including long-term problems as levels of the drug build up in the body over months and years.
“Vaccines are just designed to deliver a payload and then are quickly eliminated by the body,” Goepfert said. “This is particularly true of the mRNA vaccines. mRNA degrades incredibly rapidly. You wouldn’t expect any of these vaccines to have any long-term side effects. And in fact, this has never occurred with any vaccine.”
Vaccine side effects show up within weeks if at allThat is not to say that there have never been safety issues with vaccines. But in each instance, these have appeared soon after widespread use of the vaccine began.
“The side effects that we see occur early on, and that’s it,” Goepfert said. “In virtually all cases, vaccine side effects are seen within the first two months after rollout.”
But long-term or late effects that do not show up for the first time until years after an inoculation, as some vaccine skeptics fear, are not possible, according to the immunologists we interviewed, and are also not known from other vaccines.
This is because vaccines are rapidly broken down in the body and thus cannot trigger any lasting reactions.
The history of vaccines shows that delayed effects following vaccination can occur. But when they do, these effects tend to happen within two months of vaccination [..]
These experiences demonstrate two important findings. First, when these events occurred, the onset was within eight weeks of receipt of the vaccine. Second, in all of these cases, except narcolepsy following H1N1 vaccine, the side effect of the vaccine was something that could be caused by the infection, meaning that getting infected with the virus also carried a risk of experiencing these outcomes.
Regardless, this history humbles vaccine scientists. They know that they hold people’s lives in their hands. As stated by Dr. Maurice Hilleman, perhaps the most prolific vaccine scientist in history, “I never breathe a sigh of relief until the first few million doses are out there,” (Personal communication, Paul Offit, 2004). For this reason, scientists and public health officials carefully analyze and continually monitor the data related to every vaccine before, during and after it becomes available.
According to the Center for Countering Digital Hate, professional anti-vaccine activists organized a meeting in the fall of 2020 to create messaging that would decrease acceptance of COVID-19 vaccines once available. These organized efforts aim to move people to extreme positions about vaccines — that is to say, from having legitimate questions about vaccines to becoming “anti-vaccine,” refusing all vaccines and believing conspiracy theories and false narratives. In some cases, individuals in these groups do not believe the science, and in other cases, they are seeking to profit from this hesitancy by encouraging the use of other products to “protect” against COVID-19.
What’s more, all these and other side effects appear soon after someone has taken the vaccine, suggesting that people don’t need to worry about delayed long-term reactions.
This picture fits with the modern history of vaccinations, which shows that most new immunizations have been incredibly safe, and even the most severe effects have reared their ugly heads right away.
“Side-effects nearly always occur within a couple of weeks of a person being vaccinated,” says John Grabenstein, director of scientific communication for the Immunization Action Coalition. He adds that the longest time before a side effect appeared for any type of shot has been six weeks.
So, no vaccine has caused chronic conditions to emerge years or decades later, says Robert Jacobson, medical director of the population health science program at the Mayo Clinic. “Study after study have looked for this with all sorts of vaccines, and have not found it to be the case,” he says.
New for COVID-19, the CDC developed the V-safe app; once downloaded, vaccine recipients are asked by text messages and web surveys about any adverse events. Other programs involve long-term care facilities and large insurers tasked with flagging issues emerging in their patient populations.
The mRNA vaccines contain the blueprint, so to speak, for a specific component of the virus — after they are injected, the immune system is stimulated and antibodies are produced against this small part. Afterward, the mRNA is completely broken down again, according to BioNtech-Pfizer — and thus cannot trigger any late-onset long-term effects. "There is no evidence that reactions can occur at a later stage," Reinhold Förster said.
The rare exception to adverse events occurring within the six-week timetable is the dengue fever vaccine, Dengavaxia, which the Philippine government approved for use in their children in 2016. When people are infected with the dengue virus, their first bout of this disease is fairly mild. But when they get infected a second time, with a different strain, the reaction can be much more severe and, in some cases, fatal.
As some experts predicted, the vaccine—made from inactivated viruses—acted like a first infection, meaning many kids subsequently bitten by a dengue virus-carrying mosquito fared worse than if they hadn’t been inoculated. In 2019, the FDA approved the vaccine, but only for children in dengue-infested U.S. territories who had a laboratory-confirmed prior case of the disease.